Study of the effects of paricalcitol in a mouse model of obstructive nephropathy
Paricalcitol reduced infiltration of T cells and macrophages in the obstructed kidney and this inhibition of inflammatory cell infiltration was accompanied by a decreased expression of inflammatory cytokines. Paricalcitol attenuates renal tubulo-interstitial fibrosis in this animal model of renal obstructive damage.
Study in mice with diet-induced obesity, treated with doxercalciferol.
Doxercalciferol decreased proteinuria, podocyte injury, mesangial expansion, extracellular matrix protein accumulation, macrophage infiltration, oxidative stress, proinflammatory cytokines, and profibrotic growth factor. In addition, it prevented the activation of the renin-angiotensin-aldosterone system. VDR activation also decreased the accumulation of neutral lipids (triglycerides and cholesterol) and the expression of enzymes that mediate fatty acid and cholesterol synthesis.
