Development of Safer Gene Delivery Systems to Minimize the Risk of Insertional Mutagenesis-Related Malignancies: A Critical Issue for the Field of Gene Therapy

<table class="table-group" width="800px"><tr class="fig-image" id="a"><td><img alt="616310.fig.006a" src="https://static.hindawi.com/articles/isrn/volume-2012/616310/figures/616310.fig.006a.jpg"/></td></tr><tr class="fig-caption"><td align="center"><table><tr><td><b>(a) </b>Gamma-<i>retroviridae</i>-based vectors</td></tr></table></td></tr><tr class="fig-image" id="b"><td><img alt="616310.fig.006b" src="https://static.hindawi.com/articles/isrn/volume-2012/616310/figures/616310.fig.006b.jpg"/></td></tr><tr class="fig-caption"><td align="center"><table><tr><td><b>(b) </b>Self-inactivating <i>retroviridae</i>-based vectors</td></tr></table></td></tr></table>

<table>This figure shows a comparison between gamma-<i>retroviridae</i>- and self-inactivating-<i>retroviridae</i>-derived vector systems. The polyA signal is a more efficient transcription termination signal in the gamma-<i>retroviridae</i>-derived vector than in the self-inactivating variant.</table>

International Scholarly Research Notices

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Figure 6

Figure 6: Development of Safer Gene Delivery Systems to Minimize the Risk of Insertional Mutagenesis-Related Malignancies: A Critical Issue for the Field of Gene Therapy 

Figure 6 | Development of Safer Gene Delivery Systems to Minimize the Risk of Insertional Mutagenesis-Related Malignancies: A Critical Issue for the Field of Gene Therapy 