Altered Metabolic Profile in Congenital Lung Lesions Revealed by ¹H Nuclear Magnetic Resonance Spectroscopy

Table 3

Metabolites ratio in lung neonatal tissues. The first three ratios are obtained by ¹H 1D NMR results reported in Table 2. The PCho/GPCho ratio is derived from ¹H-¹H 2D NMR analysis: diagnostic cross peak heights of PCho and GPCho are compared to give a semiquantitative estimate of their relative concentration. Ratios and associated confidence limits are derived as reported in Experimental Section.

Metabolites ratio	Broncho pulmonary sequestration	Bronchogenic cyst	Congenital lobar emphysema	Control lung
	1D NMR	1D NMR	1D NMR	1D NMR
Lac/Glc	62.5 ± 0.5	3.91 ± 0.02	10.48 ± 0.07	3.87 ± 0.04
Lac/Creat	18.1 ± 0.2	11.9 ± 0.07	19.0 ± 0.1	24.2 ± 0.2
Myo/Glc	23.5 ± 0.1	1.44 ± 0.01	4.21 ± 0.02	0.457 ± 0.003
	2D  NMR	2D  NMR	2D  NMR	2D  NMR
PCho/GPCho	5.6 ± 0.5	0.96 ± 0.04	7.0 ± 0.2	0.41 ± 0.02