The Immune-Modulatory Role of Apolipoprotein E with Emphasis on Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis

Table 1

The main differences among apoE isoforms in humans.

Isoform	AA residues		Domain interaction	Binding to LDLR
	112	158
ApoE 2	Cysteine	Cysteine	No	Low affinity
ApoE 3	Cysteine	Arginine	No	High affinity
ApoE 4	Arginine	Arginine	Yes	High affinity

AA:amino-acid.
LDLR:low-density lipoprotein receptor.