Inhibition of Arterial Allograft Intimal Hyperplasia Using Recipient Dendritic Cells Pretreated with B7 Antisense Peptide
Figure 4
HE stained sections of the arterial grafts 2 months after transplant. (a) native carotid artery; (b) carotid arterial allograft (untreated control); (c) carotid arterial allograft (pretreated); (d) zoomed-in picture of the square fragment in Figure 4(b). Grafts in both DC-pretreated and control group showed diffused and concentric intimal thickening compared with normal nontransplanted artery (a), which is the main feature of chronic allograft rejection. However, the intima was significantly thinner in the pretreated group (c) than that in the control group (b). Also we could see more lymphocytes infiltrated within control group allografts (d).
