Multiple Roles of Myd88 in the Immune Response to the Plague F1-V Vaccine and in Protection against an Aerosol Challenge of Yersinia pestis CO92 in Mice

Figure 6

Proliferation by stimulated splenocytes from F1-V vaccinated wild-type C57BL/6 mice or Myd88-deficient C57BL/6 mice requires MyD88. Proliferation of stimulated splenocytes was determined as in Figure 3 except 2 μg of F1-V was used for stimulation in 0.25 mL. The same source of splenocytes stated in Figure 5 was used. The results are reported as mean with the standard error of the mean. Statistical significance shown above the respective bars was reported for differences between the amount of proliferation between splenocytes from wild-type C57BL/6 and Myd88-deficient C57BL/6 mice stimulated with F1-V.