Multiple Roles of Myd88 in the Immune Response to the Plague F1-V Vaccine and in Protection against an Aerosol Challenge of Yersinia pestis CO92 in Mice
Figure 9
Survival of F1-V vaccinated C57BL/6 wild-type and C57BL/6 Myd88-deficient mice after aerosol challenge with Y. pestis CO92. Mice were given two vaccinations of F1-V (2.5 μg) (see Figure 7(b)), and 33 days after the boost vaccination they were challenged by aerosol with 19 LD50 of Y. pestis CO92. There were three groups of mice that were challenged (10 mice per group): wild-type C57BL/6+adjuvant only (○); wild-type C57BL/6+F1-V (□); and C57BL/6 Myd88-deficient mice+ F1-V (∆). After challenge, the mice were followed for 21 days. The mean time to death (MTD) was the following: wild-type with adjuvant only: 4.50 days; wild-type with F1-V: 14.25 days; Myd88-deficient mice with F1-V: 5.90 days.
