An Aloe-Based Composition Constituting Polysaccharides and Polyphenols Protected Mice against D-Galactose-Induced Immunosenescence

Figure 7

Effect of UP360 on humoral immunity and oxidative stress markers. Mice (n = 10) were injected with D-galactose at 500 mg/kg subcutaneously daily for 9 weeks to induce accelerated aging. Mice were treated with two doses of UP360 (200 or 400 mg/kg) orally starting at week 5 and immunized at the end of week 7 (start of week 8) with 3 μg of Fluarix quadrivalent vaccine. Necropsy was carried out 14 days after vaccination at the end of week 9. Serum ELISA data for immunoglobulin A (Figure 6(a)) and SOD (Figure 6(b)) and spleen homogenate (Figure 6(c)) data for Nrf2 are reported as mean ± SD. vs D-gal control; vs D-gal control.

(a)

(b)

(c)