Coupling Strategies for the Synthesis of Peptide-Oligonucleotide Conjugates for Patterned Synthetic Biomineralization

Figure 2

PAGE analysis of reactions 1–3 from Table 1. The coupling reagents used in lanes 1, 2, and 3 are HBTU, PyBOP, and DMTMM, respectively. As demonstrated by the control lane, starting material (SM) is below the slower-moving peptide-oligonucleotide conjugate (POC).