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Journal of Nanomaterials
Volume 2012 (2012), Article ID 891318, 7 pages
http://dx.doi.org/10.1155/2012/891318
Research Article

Nanoparticles in Cancer Imaging and Therapy

1Institute of Medical Physics, School of Physics, The University of Sydney, Sydney, N.S.W 2006, Australia
2Plasma Nanoscience Centre Australia (PNCA), CSIRO Materials Science and Engineering, P.O. Box 218, Lindfield, N.S.W 2070, Australia

Received 10 February 2012; Accepted 3 March 2012

Academic Editor: Krasimir Vasilev

Copyright © 2012 Leon Smith et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. P. Suetens, Fundamentals of Medical Imaging, Cambridge University Press, New York, NY, USA, 2nd edition, 2009.
  2. P. Jackson, S. Periasamy, V. Bansal, and M. Geso, “Evaluation of the effects of gold nanoparticle shape and size on contrast enhancement in radiological imaging,” Australasian Physical and Engineering Sciences in Medicine, vol. 34, no. 2, pp. 243–249, 2011. View at Publisher · View at Google Scholar · View at Scopus
  3. J. F. Hainfeld, D. N. Slatkin, T. M. Focella, and H. M. Smilowitz, “Gold nanoparticles: a new X-ray contrast agent,” British Journal of Radiology, vol. 79, no. 939, pp. 248–253, 2006. View at Publisher · View at Google Scholar · View at Scopus
  4. C. Fang and M. Zhang, “Multifunctional magnetic nanoparticles for medical imaging applications,” Journal of Materials Chemistry, vol. 19, no. 35, pp. 6258–6266, 2009. View at Publisher · View at Google Scholar · View at Scopus
  5. D. Kim, M. K. Yu, T. S. Lee, J. J. Park, Y. Y. Jeong, and S. Jon, “Amphiphilic polymer-coated hybrid nanoparticles as CT/MRI dual contrast agents,” Nanotechnology, vol. 22, no. 15, Article ID 155101, 2011. View at Publisher · View at Google Scholar · View at Scopus
  6. H. M. Garnica-Garza, “Contrast-enhanced radiotherapy: feasibility and characteristics of the physical absorbed dose distribution for deep-seated tumors,” Physics in Medicine and Biology, vol. 54, no. 18, pp. 5411–5425, 2009. View at Publisher · View at Google Scholar · View at Scopus
  7. D. K. Chatterjee, L. S. Fong, and Y. Zhang, “Nanoparticles in photodynamic therapy: an emerging paradigm,” Advanced Drug Delivery Reviews, vol. 60, no. 15, pp. 1627–1637, 2008. View at Publisher · View at Google Scholar · View at Scopus
  8. B. C. Wilson and M. S. Patterson, “The physics, biophysics and technology of photodynamic therapy,” Physics in Medicine and Biology, vol. 53, no. 9, pp. R61–R109, 2008. View at Publisher · View at Google Scholar · View at Scopus
  9. A. K. L. Yuen, G. A. Hutton, A. F. Masters, and T. Maschmeyer, “The interplay of catechol ligands with nanoparticulate iron oxides,” Dalton Transactions, vol. 41, no. 9, pp. 2545–2559, 2012.
  10. R. S. Mello, H. Callison, J. Winter, A. R. Kagan, and A. Norman, “Radiation dose enhancement in tumors with iodine,” Medical Physics, vol. 10, no. 1, pp. 75–78, 1983.
  11. A. V. Mesa, A. Norman, T. D. Solberg, J. J. Demarco, and J. B. Smathers, “Dose distributions using kilovoltage X-rays and dose enhancement from iodine contrast agents,” Physics in Medicine and Biology, vol. 44, no. 8, pp. 1955–1968, 1999. View at Publisher · View at Google Scholar · View at Scopus
  12. J. H. Rose, A. Norman, and M. Ingram, “First experience with radiation therapy of small brain tumors delivered by a computerized tomography scanner,” International Journal of Radiation Oncology Biology Physics, vol. 30, pp. 1127–1132, 1994.
  13. F. Verhaegen, B. Reniers, F. Deblois, S. Devic, J. Seuntjens, and D. Hristov, “Dosimetric and microdosimetric study of contrast-enhanced radiotherapy with kilovolt x-rays,” Physics in Medicine and Biology, vol. 50, no. 15, pp. 3555–3569, 2005. View at Publisher · View at Google Scholar · View at Scopus
  14. A. R. Kagan, R. J. Steckel, P. Cancilla, G. Juillard, and T. Patin, “The pathogenesis of brain necrosis: time and dose parameters,” International Journal of Radiation Oncology Biology Physics, vol. 1, no. 7-8, pp. 729–732, 1976. View at Scopus
  15. S. J. McMahon, M. H. Mendenhall, S. Jain, and F. Currell, “Radiotherapy in the presence of contrast agents: a general figure of merit and its application to gold nanoparticles,” Physics in Medicine and Biology, vol. 53, no. 20, pp. 5635–5651, 2008. View at Publisher · View at Google Scholar · View at Scopus
  16. R. I. Berbecoa, W. Ngwaa, and M. Makrigiorgosa, “Localized dose enhancement to tumor blood vessel endothelial cells via targeted gold nanoparticles: new potential for external beam radiotherapy,” International Journal of Radiation Oncology Biology Physics, vol. 78, pp. S649–S650, 2010.
  17. D. B. Chithrani, S. Jelveh, F. Jalali et al., “Gold nanoparticles as radiation sensitizers in cancer therapy,” Radiation Research, vol. 173, no. 6, pp. 719–728, 2010. View at Publisher · View at Google Scholar · View at Scopus
  18. J. F. Hainfeld, F. A. Dilmanian, D. N. Slatkin, and H. M. Smilowitz, “Radiotherapy enhancement with gold nanoparticles,” The Journal of Pharmacy and Pharmacology, vol. 60, no. 8, pp. 977–985, 2008. View at Publisher · View at Google Scholar · View at Scopus
  19. J. F. Hainfeld, D. N. Slatkin, and H. M. Smilowitz, “The use of gold nanoparticles to enhance radiotherapy in mice,” Physics in Medicine and Biology, vol. 49, no. 18, pp. N309–N315, 2004. View at Publisher · View at Google Scholar · View at Scopus
  20. Y. Zheng, P. Cloutier, D. J. Hunting, and L. Sanche, “Radiosensitization by gold nanoparticles: comparison of DNA damage induced by low and high-energy electrons,” Journal of Biomedical Nanotechnology, vol. 4, no. 4, pp. 469–473, 2008. View at Publisher · View at Google Scholar · View at Scopus
  21. S. Bhattacharyya, R. A. Kudgus, R. Bhattacharya, and P. Mukherjee, “Inorganic nanoparticles in cancer therapy,” Pharmaceutical Research, vol. 28, no. 2, pp. 237–259, 2011. View at Publisher · View at Google Scholar · View at Scopus
  22. S. J. McMahon, W. B. Hyland, M. F. Muir, et al., “Biological consequences of nanoscale energy deposition near irradiated heavy atom nanoparticles,” Scientific Reports, vol. 1, article 18, 2011. View at Publisher · View at Google Scholar
  23. M. K. K. Leung, J. C. L. Chow, B. D. Chithrani, M. J. G. Lee, B. Oms, and D. A. Jaffray, “Irradiation of gold nanoparticles by X-rays: Monte Carlo simulation of dose enhancements and the spatial properties of the secondary electrons production,” Medical Physics, vol. 38, no. 2, pp. 624–631, 2011. View at Publisher · View at Google Scholar · View at Scopus
  24. A. Anshup, J. S. Venkataraman, C. Subramaniam et al., “Growth of gold nanoparticles in human cells,” Langmuir, vol. 21, no. 25, pp. 11562–11567, 2005. View at Publisher · View at Google Scholar · View at Scopus
  25. S. Jain, J. A. Coulter, A. R. Hounsell et al., “Cell-Specific Radiosensitization by gold nanoparticles at megavoltage radiation energies,” International Journal of Radiation Oncology Biology Physics, vol. 79, no. 2, pp. 531–539, 2011. View at Publisher · View at Google Scholar · View at Scopus
  26. M. Triesscheijn, P. Baas, J. H. M. Schellens, and F. A. Stewart, “Photodynamic therapy in oncology,” Oncologist, vol. 11, no. 9, pp. 1034–1044, 2006. View at Publisher · View at Google Scholar · View at Scopus
  27. D. K. Chatterjee and Z. Yong, “Upconverting nanoparticles as nanotransducers for photodynamic therapy in cancer cells,” Nanomedicine, vol. 3, no. 1, pp. 73–82, 2008. View at Publisher · View at Google Scholar · View at Scopus
  28. R. R. Allison, V. S. Bagnato, and C. H. Sibata, “Future of oncologic photodynamic therapy,” Future Oncology, vol. 6, no. 6, pp. 929–940, 2010. View at Publisher · View at Google Scholar · View at Scopus
  29. S. Yamaguchi, H. Kobayashi, T. Narita et al., “Sonodynamic therapy using water-dispersed TiO2-polyethylene glycol compound on glioma cells: comparison of cytotoxic mechanism with photodynamic therapy,” Ultrasonics Sonochemistry, vol. 18, no. 5, pp. 1197–1204, 2011. View at Publisher · View at Google Scholar · View at Scopus
  30. R. R. Allison, G. H. Downie, R. Cuenca, X.-H. Hu, C. J. H. Childs, and C. H. Sibata, “Photosensitizers in clinical PDT,” Photodiagnosis and Photodynamic Therapy, vol. 1, no. 1, pp. 27–42, 2004. View at Publisher · View at Google Scholar · View at Scopus
  31. M. K. K. Oo, Multifunctional Gold Nanoparticles For Photodynamic Therapy of Cancer, Stevens Institute of Technology, Hoboken, NJ, USA, 2010.
  32. M. Kuruppuarachchi, H. Savoie, A. Lowry, C. Alonso, and R. W. Boyle, “Polyacrylamide nanoparticles as a delivery system in photodynamic therapy,” Molecular Pharmaceutics, vol. 8, no. 3, pp. 920–931, 2011. View at Publisher · View at Google Scholar · View at Scopus
  33. P. Couleaud, V. Morosini, C. Frochot, S. Richeter, L. Raehm, and J.-O. Durand, “Silica-based nanoparticles for photodynamic therapy applications,” Nanoscale, vol. 2, no. 7, pp. 1083–1095, 2010. View at Publisher · View at Google Scholar · View at Scopus
  34. M. Zeisser-Labouebe, N. Lange, R. Gurny, and F. Delie, “Hypericin-loaded nanoparticles for the photodynamic treatment of ovarian cancer,” International Journal of Pharmaceutics, vol. 326, no. 1-2, pp. 174–181, 2006. View at Publisher · View at Google Scholar · View at Scopus
  35. E. Allemann, N. Brasseur, O. Benrezzak et al., “PEG-coated poly(lactic acid) nanoparticles for the delivery of hexadecafluoro zinc phthalocyanine to EMT-6 mouse mammary tumours,” The Journal of Pharmacy and Pharmacology, vol. 47, no. 5, pp. 382–387, 1995. View at Scopus
  36. V. Saxena, M. Sadoqi, and J. Shao, “Polymeric nanoparticulate delivery system for indocyanine green: biodistribution in healthy mice,” International Journal of Pharmaceutics, vol. 308, no. 1-2, pp. 200–204, 2006. View at Publisher · View at Google Scholar · View at Scopus
  37. E. Ricci-Junior and J. M. Marchetti, “Zinc(II) phthalocyanine loaded PLGA nanoparticles for photodynamic therapy use,” International Journal of Pharmaceutics, vol. 310, no. 1-2, pp. 187–195, 2006. View at Publisher · View at Google Scholar · View at Scopus
  38. L. Liu, P. Miao, Y. Xu, Z. Tian, Z. Zou, and G. Li, “Study of Pt/Tio2 nanocomposite for cancer-cell treatment,” Journal of Photochemistry and Photobiology B, vol. 98, no. 3, pp. 207–210, 2010. View at Publisher · View at Google Scholar · View at Scopus
  39. S. Yamaguchi, H. Kobayashi, T. Narita et al., “Novel photodynamic therapy using water-dispersed TiO2 polyethylene glycol compound: evaluation of antitumor effect on glioma cells and spheroids in vitro,” Photochemistry and Photobiology, vol. 86, no. 4, pp. 964–971, 2010. View at Publisher · View at Google Scholar · View at Scopus
  40. A. Janczyk, A. Wolnicka-Głubisz, K. Urbanska, H. Kisch, G. Stochel, and W. Macyk, “Photodynamic activity of platinum(IV) chloride surface-modified TiO2 irradiated with visible light,” Free Radical Biology and Medicine, vol. 44, no. 6, pp. 1120–1130, 2008. View at Publisher · View at Google Scholar · View at Scopus
  41. E. Fabian, R. Landsiedel, L. Ma-Hock, K. Wiench, W. Wohlleben, and B. van Ravenzwaay, “Tissue distribution and toxicity of intravenously administered titanium dioxide nanoparticles in rats,” Archives of Toxicology, vol. 82, no. 3, pp. 151–157, 2008. View at Publisher · View at Google Scholar · View at Scopus
  42. B. K. Bernard, M. R. Osheroff, A. Hofmann, and J. H. Mennear, “Toxicology and carcinogenesis studies of dietary titanium dioxide-coated mica in male and female Fischer 344 rats,” Journal of Toxicology and Environmental Health, vol. 29, no. 4, pp. 417–429, 1990. View at Scopus
  43. F. Bischoff and G. Bryson, “Tissue reaction to and fate of parenterally administered titanium dioxide. I. The intraperitoneal site in male Marsh-Buffalo mice,” Research Communications in Chemical Pathology and Pharmacology, vol. 38, no. 2, pp. 279–290, 1982. View at Scopus
  44. C. Yu, T. Canteenwala, M. E. El-Khouly et al., “Efficiency of singlet oxygen production from self-assembled nanospheres of molecular micelle-like photosensitizers FC4S,” Journal of Materials Chemistry, vol. 15, no. 18, pp. 1857–1864, 2005. View at Publisher · View at Google Scholar · View at Scopus
  45. B. Ungun, R. K. Prud'homme, S. J. Budijono et al., “Nanofabricated upconversion nanoparticles for photodynamic therapy,” Optics Express, vol. 17, no. 1, pp. 80–86, 2009. View at Publisher · View at Google Scholar · View at Scopus
  46. C. Guy and D. Ffytche, An Introduction to The Principles of Medical Imaging, Imperial College Press, London, UK, 2005.
  47. T. D. Schladt, K. Schneider, M. I. Shukoor et al., “Highly soluble multifunctional MnO nanoparticles for simultaneous optical and MRI imaging and cancer treatment using photodynamic therapy,” Journal of Materials Chemistry, vol. 20, no. 38, pp. 8297–8304, 2010. View at Publisher · View at Google Scholar · View at Scopus
  48. W.-Y. Huang and J. J. Davis, “Multimodality and nanoparticles in medical imaging,” Dalton Transactions, vol. 40, no. 23, pp. 6087–6103, 2011. View at Publisher · View at Google Scholar · View at Scopus
  49. E. B. Podgorsak, Radiation Oncology Physics: A Handbook for Teachers and Students, IAEA, Vienna, Austria, 2005.
  50. B.-J. Schultz, P. Wust, L. Ludemann, G. Jost, and H. Pietsch, “Monte Carlo simulation of contrast-enhanced whole brain radiotherapy on a CT scanner,” Medical Physics, vol. 38, no. 8, pp. 4672–4680, 2011. View at Publisher · View at Google Scholar · View at Scopus