OR (95% CI) for low BMD per category folate status: 1: FA < 3.8 nmol/L 2: FA 3.8–4.9 nmol/L 3: FA 5.0–8.4 nmol/L 4: FA ≥ 8.5 nmol/L + P for trend Multivariate regression for folate-BMD β (SE) (per 50 nmol/L)
♀: 1: 1.55 (1.07–2.23) 2: 1.18 (0.86–1.63) 3: 1.24 (0.99–1.56) 4: 1.00 (reference) P for trend = 0.02
♂: 0.81 (0.53–1.24) 0.96 (0.67–1.38) 1.15 (0.87–1.53) 1.00 (reference) P for trend = 0.26g
Stepwise multivariate regression, β for association folate-BMD β + P value
Premenopausal: LS: 3.31 (4.73) P = 0.490m, 2 FN: 1.32 (4.90) P = 0.791m, 2 TH: 2.87 (4.35) P = 0.516m, 2 Postmenopausal: LS: −3.75 (3.47) P = 0.284m, 2 FN: −1.32 (3.15) P = 0.679m, 2 TH: 0.66 (3.89) P = 0.862m, 2
*Serum/plasma folate concentrations were converted to nmol/L if applicable, using the following equation: 1 ng/ml = 2.266 nmol/L. Subsequent outcomes were also converted. Where possible, subgroups were combined. BMD sites—LS: Lumbar Spine, FN: Femoral Neck, TH: Total Hip #data presented in article as μmol/L, this is presumably a typing error and should be nmol/L.
1β (SE) as calculated from data provided by author; 2β (SE) as calculated from presented data.
aadjusted for age, BMI, smoking, coffee intake, physical activity, vit D use, educational level, estrogen use in women; badjusted for sex, age, height, weight, estrogen use in women; cadjusted for age, gender, education, osteoporosis drug, serum creatinine, tHcy; dAdjusted for duration of menopause, smoking, BMI, B12, tHcy; eadjusted for age, BMI, logtHcy, logB12, creatinine clearance, smoking, alcohol intake;
fAdjusted for age, weight, weight change; gAdjusted for smoking, BMI, creatinin, coffee intake, physical activity, use of estrogen therapy; hadjusted for age, BMI, alkaline phosphatase; iadjusted for years since menopause, BMI, alkaline phosphatase, creatinine; jadjusted for age, B12, tHcy, PTH, CTx, Ca, Cr; kAdjusted for age, sex, ethnicity, BMI, smoking, physical activity, creatinin, alcohol, coffee, energy, calcium, vitamin D zinc intake; Ladjusted for age, BMI, tHcy, B12; madjusted for Age, BMI, smoking, alcohol, physical activity, tHcy, B12.