686952.fig.005
Figure 5: Effect of a high-fat diet and treatment with AVE7688 on calcitonin gene-related peptide-(CGRP)-mediated vascular relaxation of epineurial arterioles. Rats were fed a standard or high-fat diet with or without AVE7688, Enalapril, or Candoxatril for 24 weeks. Arterioles were derived from rats as described in Figure 4. Incremental doses of CGRP were added to the bathing solution while recording steady state vessel diameter. Data are presented as the mean of % relaxation ± SEM. The number of rats in each group was the same as shown in Table 1. , compared to rats fed the standard diet (control), , compared to rats fed the high-fat diet.