Table 1: (a) FTO variation and BMI in populations of African ancestry and (b) degree of linkage disequilibrium between FTO SNPs in Table 1(a) in the YRI population [12].
(a)

FTO SNPPopulation (n, study, reference)Minor allele
Minor allele frequency (affected/control)P value
(for relationship with BMI)

rs9939609 AA children (Cincinnati) (n = 497) [13]A0.480.87
AA children (GCTS, LACHY, APEX)
(n = 1025) [14]
A0.4460.02
AA adults (IRAS-FS) (n = 604) [15] A0.4910.014
AA adults (IRAS) (n = 288) [16]A0.4180.71
South African adults (birth to age 20)
(n = 990) [17]
A0.470.029/0.071
AA adults (Jackson heart study) (n = 4042) [18]A0.4690.4125
AA adults Maywood (n = 775) [18]A0.4170.5735
African-derived adults (WA, AA) (n = 1,485) [19]A0.504 (WA)
0.467 (AA)
0.768 (WA)
0.136 (AA)

rs8050136AA children (CHOP) (n = 2,002) [20]A0.449/0.437
AA children (Cincinnati) (n = 497) [13]A0.430.87
AA adults (IRAS-FS) (n = 604) [15]A0.4830.011
AA adults (IRAS) (n = 288) [16]A0.3910.20
South African adults (birth to age 20)
(n = 990) [17]
A0.420.021/0.057
AA adults (Jackson heart study)
(n = 4,042) [18]
A0.4241
AA adults (MEC) (n = 3,482) [18] A0.4360.2990
African-derived (Jamaica Spanish Town)
(n = 1407) [18]
A0.4600.9899
African-derived adults (G × E) (n = 938) [18]A0.4520.8774
AA adults Maywood (n = 775) [18]A0.4720.6404
Meta-analysis 6 AA cohorts (n = 4992) [21]A0.450.141

rs3751812AA children (CHOP) (n = 2,002) [20]T0.115/0.0900.017
AA children (Cincinnati) (n = 497) [13]T0.120.86
AA adults (GenNet) (n = 1,101) [22] T0.110.8
AA adults (IRAS-FS) (n = 604) [15]T0.1430.38
AA adults (IRAS) (n = 288) [16]T0.0830.22
South African adults (birth to age 20)
(n = 990) [17]
T
African-derived adults Meta-analysis
(n = 10,819) [18]
T0.078–0.117

rs8057044 AA children (Cincinnati) (n = 497) [13]G0.300.00054 (unadj)
AA adults (IRAS-FS) (n = 604) [15]G0.2460.053
AA adults (IRAS) (n = 288) [16]G0.3140.039
AA adults (Jackson heart study)
(n = 4,042) [18]
G0.2831
AA adults (MEC) (n = 3,482) [18] G0.3010.1476
AA adults Maywood (n = 775) [18]G0.250.6121
Meta-analysis 6 AA cohorts (n = 4,992) [21]G0.270.710
African-derived adults (WA, AA) (n = 1,485) [19]G0.27 (WA)
0.27 (AA)
NS

rs1108102AA adults (IRAS) (n = 288) [16]A0.125
Meta-analysis 6 AA cohorts (n = 4,992) [21]A0.150.636
African-derived adults (WA, AA) (n = 1,485) [19]A0.1860.142

rs17817449South African adults (birth to age 20)
(n = 990) [17]
G0.370.008/0.022
AA adults Maywood (n = 775) [18]G0.3610.1513
African-derived adults (WA, AA) (n = 1,485) [19]G0.409 (WA)
0.396 (AA)
0.554 (WA)
0.151 (AA)

rs9941349African-derived adults meta-analysis
(n = 10,819) [18]
T0.167–0.191
African-derived adults (WA, AA) (n = 1,485) [19]T0.165 (WA)
0.187 (AA)
NS

(b)

(YRI)rs9939609rs8050136rs3751812rs8057044rs1108102rs17817449rs9941349

rs99396091
rs80501360.8431
rs37518120.0570.0681
rs80570440.0650.1190.0141
rs11081020.0300.0500.0160.0441
rs178174490.6210.7360.0920.1510.0241
rs99413490.0090.0330.3560.0000.0180.0051