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Journal of Obesity
Volume 2014 (2014), Article ID 647034, 6 pages
http://dx.doi.org/10.1155/2014/647034
Research Article

Extra Fructose in the Growth Medium Fuels Lipogenesis of Adipocytes

Department of Laboratory Medicine, Donauspital, SMZ Ost, Langobardenstraße 122, 1220 Vienna, Austria

Received 23 October 2013; Revised 16 January 2014; Accepted 16 January 2014; Published 19 February 2014

Academic Editor: R. Prager

Copyright © 2014 Armin Robubi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Fructose in excessive amounts exerts negative effects on insulin sensitivity, blood pressure, and liver metabolism. These adverse outcomes were attributed to its disturbances of key metabolic pathways in the liver. Recently, possible consequences of high fructose levels directly on adipocytes in vivo have been considered. We have cultured adipocytes in growth media containing 1 g/L fructose additionally to glucose and monitored the cells fate. Cells developed lipid vesicles much earlier with fructose and showed altered kinetics of the expression of mRNAs involved in lipogenesis and hexose uptake. Adiponectin secretion, too, peaked earlier in fructose containing media than in media with glucose only. From these data it can be speculated that similar effects of fructose containing diets happen in vivo also. Apart from toxic action on liver cells, adipocytes might be stimulated to take up extra fructose and generate new lipid vesicles, further dysregulating energy homeostasis.