About this Journal Submit a Manuscript Table of Contents
Journal of Obesity
Volume 2014 (2014), Article ID 647034, 6 pages
http://dx.doi.org/10.1155/2014/647034
Research Article

Extra Fructose in the Growth Medium Fuels Lipogenesis of Adipocytes

Department of Laboratory Medicine, Donauspital, SMZ Ost, Langobardenstraße 122, 1220 Vienna, Austria

Received 23 October 2013; Revised 16 January 2014; Accepted 16 January 2014; Published 19 February 2014

Academic Editor: R. Prager

Copyright © 2014 Armin Robubi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. Brauna, K. Bitton-Worms, and D. le Roith, “The link between the metabolic syndrome and cancer,” International Journal of Biological Sciences, vol. 7, no. 7, pp. 1003–1015, 2011. View at Scopus
  2. J. C. K. Wells, “Obesity as malnutrition: the role of capitalism in the obesity global epidemic,” The American Journal of Human Biology, vol. 24, no. 3, pp. 261–276, 2012. View at Publisher · View at Google Scholar · View at Scopus
  3. S. N. Bleich, Y. C. Wang, Y. Wang, and S. L. Gortmaker, “Increasing consumption of sugar-sweetened beverages among US adults: 1988–1994 to 1999–2004,” The American Journal of Clinical Nutrition, vol. 89, no. 1, pp. 372–381, 2009. View at Publisher · View at Google Scholar · View at Scopus
  4. R. J. Johnson, S. E. Perez-Pozo, Y. Y. Sautin et al., “Hypothesis: could excessive fructose intake and uric acid cause type 2 diabetes?” Endocrine Reviews, vol. 30, no. 1, pp. 96–116, 2009. View at Publisher · View at Google Scholar · View at Scopus
  5. D. Faeh, K. Minehira, J.-M. Schwarz, R. Periasami, S. Park, and L. Tappy, “Effect of fructose overfeeding and fish oil administration on hepatic de novo lipogenesis and insulin sensitivity in healthy men,” Diabetes, vol. 54, no. 7, pp. 1907–1913, 2005. View at Publisher · View at Google Scholar · View at Scopus
  6. V. S. Malik, B. M. Popkin, G. A. Bray, J.-P. Després, W. C. Willett, and F. B. Hu, “Sugar-sweetened beverages and risk of metabolic syndrome and type 2 diabetes: a meta-analysis,” Diabetes Care, vol. 33, no. 11, pp. 2477–2483, 2010. View at Publisher · View at Google Scholar · View at Scopus
  7. R. H. Lustig, “Fructose: metabolic, hedonic, and societal parallels with ethanol,” Journal of the American Dietetic Association, vol. 110, no. 9, pp. 1307–1321, 2010. View at Scopus
  8. T. Ishimoto, M. A. Lanaspa, C. J. Rivard, et al., “High fat and high sucrose (western) diet induce steatohepatitis that is dependent on fructokinase,” Hepatology, vol. 58, no. 5, pp. 1632–1643, 2013. View at Publisher · View at Google Scholar
  9. E. Hajduch, F. Darakhshan, and H. S. Hundal, “Fructose uptake in rat adipocytes: GLUT5 expression and the effects of streptozotocin-induced diabetes,” Diabetologia, vol. 41, no. 7, pp. 821–828, 1998. View at Publisher · View at Google Scholar · View at Scopus
  10. T. Ishimoto, M. A. Lanaspa, M. T. Le et al., “Opposing effects of fructokinase C and A isoforms on fructose-induced metabolic syndrome in mice,” Proceedings of the National Academy of Sciences of the United States of America, vol. 109, no. 11, pp. 4320–4325, 2012. View at Publisher · View at Google Scholar · View at Scopus
  11. E. J. Hajduch, M. C. Guere-Millo, I. A. Hainault, C. M. Guichard, and M. M. Lavau, “Expression of glucose transporters (GLUT 1 and GLUT 4) in primary cultured rat adipocytes: differential evolution with time and chronic insulin effect,” Journal of Cellular Biochemistry, vol. 49, no. 3, pp. 251–258, 1992. View at Publisher · View at Google Scholar · View at Scopus
  12. K. Rabe, M. Lehrke, K. G. Parhofer, and U. C. Broedl, “Adipokines and insulin resistance,” Molecular Medicine, vol. 14, no. 11-12, pp. 741–751, 2008. View at Publisher · View at Google Scholar · View at Scopus
  13. C. F. Semenkovich, T. Coleman, and F. T. Fiedorek Jr., “Human fatty acid synthase mRNA: tissue distribution, genetic mapping, and kinetics of decay after glucose deprivation,” Journal of Lipid Research, vol. 36, no. 7, pp. 1507–1521, 1995. View at Scopus
  14. F. P. Kuhajda, S. Aja, Y. Tu et al., “Pharmacological glycerol-3-phosphate acyltransferase inhibition decreases food intake and adiposity and increases insulin sensitivity in diet-induced obesity,” The American Journal of Physiology—Regulatory Integrative and Comparative Physiology, vol. 301, no. 1, pp. R116–R130, 2011. View at Publisher · View at Google Scholar · View at Scopus