Lymphatics and Lymphangiogenesis in the Eye

Table 2

Lymphatic-associated ocular diseases. The list shows several diseases of the eye that are related to lymphatics or lymphangiogenesis. Further investigation might provide evidence of the contribution of lymphatics or lymphangiogenesis in the other eye diseases.

Eye diseases	Possible role of lymphatics	Reference
Corneal transplant	Lymphatic vessels but not angiogenic vessels are important for the immune rejection	[50]
Dry eye	Dry eye, which is a low-grade corneal inflammatory disorder, induces lymphangiogenesis	[49]
HSV-1 keratitis	Corneal herpes simplex virus-1 infection induces lymphangiogenesis via VEGF-A	[48]
Glaucoma	“Uveolymphatic pathway”; lymphatics exists in the ciliary body	[51]
Intraocular tumors	“Tumor-associated lymphangiogenesis” correlates the malignancy	[52, 53]