Circulating Th17, Th22, and Th1 Cells Are Elevated in the Guillain-Barré Syndrome and Downregulated by IVIg Treatments

Figure 2

Percentages of circulating Th1 (IFN-𝛾⁺IL-17A⁻IL-22⁻), Th1/Th17 (IFN-𝛾⁺IL-17A⁺IL-22⁻), Th17 (IFN-𝛾⁻IL-17A⁺IL-22⁻, IFN-𝛾⁻IL-17A⁺IL-22⁺) and Th22 (IFN-𝛾⁻IL-17A⁻IL-22⁺) cells on CD4⁺ cells of GBS, ONIDs and HC. (a) Representative four-color dot plot analyses of Th1, Th1/Th17 cells on CD4⁺ IFN-𝛾⁺ (gate I) cells and Th17 (IFN-𝛾⁻IL-17A⁺IL-22⁻, IFN-𝛾⁻IL-17A⁺IL-22⁺), Th22 cells on CD4⁺ IFN-𝛾⁻ (gate II) cells from the same GBS patient in Figure 1(a). (b) The percentages of Th1, Th1/Th17, Th17 (IFN-𝛾⁻IL-17A⁺IL-22⁻, IFN-𝛾⁻IL-17A⁺IL-22⁺) and Th22 cells on CD4⁺ cells in each group. Results are represented as the mean ± SD. Statistical significance was indicated: ^∗𝑃<0.05, ^∗∗𝑃<0.01, ^∗∗∗𝑃<0.001.

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