Age-Dependent Switch of the Role of Serotonergic 5-HT_1A Receptors in Gating Long-Term Potentiation in Rat Visual Cortex In Vivo

Figure 2

The effect of application (in V1 by means of reverse microdialysis; application started 20 min prior to the onset of recordings) of either aCSF (adult and immature animals), 5-HT (0.1 and 10 mM; adults), WAY 100635 (1 mM; adults and immature), methiothepin (1 mM; adults), or 8-OH-DPAT (1 mM; adults) on baseline (pre-TBS delivery) amplitude of fPSP recorded in V1. Each bar represents averaged fPSP amplitudes during 30 min (i.e., 60 fPSPs) of baseline recordings. The high concentration of 5-HT (10 mM) resulted in a significant (; -test) depression of fPSP amplitude compared to aCSF application. None of the other pharmacological treatments resulted in a significant change of fPSP amplitudes relative to aCSF application. indicates a significant (, -test) difference between the two groups.