Age-Dependent Switch of the Role of Serotonergic 5-HT_1A Receptors in Gating Long-Term Potentiation in Rat Visual Cortex In Vivo

Figure 3

The effect of application (in V1 by means of reverse microdialysis) of either aCSF () or 5-HT (0.1 or 10 mM; and 7, resp.) on LTP following TBS (at arrow) of the LGN in urethane-anesthetized rats. Application of 5-HT did not result in any significant changes in LTP relative to rats receiving aCSF. Inserts depict typical fPSPs before (red) and after (blue) LTP induction for animals in the presence of 0.1 mM 5-HT (top), 10 mM 5-HT (middle), or aCSF (bottom; calibration bars indicate 0.5 mV vertical and 10 ms horizontal; each fPSP trace is an average of 30 min of continuous recording).