Age-Dependent Switch of the Role of Serotonergic 5-HT_1A Receptors in Gating Long-Term Potentiation in Rat Visual Cortex In Vivo

Figure 7

The effect of application (in V1 by means of reverse microdialysis) of either aCSF () or WAY 100635 (1 mM, ) on LTP following TBS (at arrow) of the LGN in juvenile (mean age 45 days, range 42–48 days), urethane-anesthetized rats. Application of WAY 100635 resulted in a suppression of LTP relative to animals receiving aCSF during four of the last five 10 min recording epochs relative to animals receiving aCSF. Inserts depict typical fPSPs before (red) and after (blue) LTP induction in the presence of aCSF (top) and WAY 100635 (bottom; calibration bars indicate 0.5 mV vertical and 10 ms horizontal; each fPSP trace is an average of 30 min of continuous recording). indicates a significant (, -test) difference between the two groups.