Age-Dependent Switch of the Role of Serotonergic 5-HT_1A Receptors in Gating Long-Term Potentiation in Rat Visual Cortex In Vivo

Figure 8

The effect of application (in V1 by means of reverse microdialysis; starting 20 min prior to the onset of recordings) of either aCSF, 5-HT (top; 0.1 and 10 mM), WAY 100635 (middle; 1 mM), or methiothepin (bottom; 1 mM) on electrocorticographic (ECoG) activity in V1 of adult, urethane-anesthetized rats. The ECoG was recorded and analyzed (5 sec epochs) by power spectral analysis before the onset of baseline recordings and at the end of the experiment. Throughout the experiment, ECoG activity was dominated by large amplitude, slow activity, with most power concentrated in the low delta (0.5–1 Hz) and delta (1–4 Hz) frequency bands. None of the pharmacological treatments resulted in a significant change in ECoG activity. Insert depicts typical ECoG activity in V1, with the shaded area representing a 5 sec epoch used for the analysis (group sizes the same as those in previous figures).

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