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Oxidative Medicine and Cellular Longevity
Volume 2012 (2012), Article ID 374346, 9 pages
Modified High-Sucrose Diet-Induced Abdominally Obese and Normal-Weight Rats Developed High Plasma Free Fatty Acid and Insulin Resistance
1Division of Geriatrics, West China Hospital of Sichuan University, Chengdu 610041, China
2Division of Endocrinology and Metabolism, West China Hospital of Sichuan University, Chengdu 610041, China
3Division of Endocrinology, The Fifth People’s Hospital of Chengdu, Chengdu 611130, China
Received 29 June 2012; Revised 31 October 2012; Accepted 26 November 2012
Academic Editor: Peter Adhihetty
Copyright © 2012 Li Cao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- N. B. Ruderman, S. H. Schneider, and P. Berchtold, “The “metabolically-obese,” normal-weight individual,” American Journal of Clinical Nutrition, vol. 34, no. 8, pp. 1617–1621, 1981.
- E. Molero-Conejo, L. M. Morales, V. Fernández et al., “Lean adolescents with increased risk for metabolic syndrome,” Archivos Latinoamericanos de Nutricion, vol. 53, no. 1, pp. 39–46, 2003.
- R. V. Dvorak, W. F. DeNino, P. A. Ades, and E. T. Poehlman, “Phenotypic characteristics associated with insulin resistance in metabolically obese but normal-weight young women,” Diabetes, vol. 48, no. 11, pp. 2210–2214, 1999.
- M. P. St-Onge, I. Janssen, and S. B. Heymsfield, “Metabolic syndrome in normal-weight Americans: new definition of the metabolically obese, normal-weight individual,” Diabetes Care, vol. 27, no. 9, pp. 2222–2228, 2004.
- F. Conus, D. B. Allison, R. Rabasa-Lhoret et al., “Metabolic and behavioral characteristics of metabolically obese but normal-weight women,” Journal of Clinical Endocrinology and Metabolism, vol. 89, no. 10, pp. 5013–5020, 2004.
- Y. W. Park, S. Zhu, L. Palaniappan, S. Heshka, M. R. Carnethon, and S. B. Heymsfield, “The metabolic syndrome: prevalence and associated risk factor findings in the US population from the Third National Health and Nutrition Examination Survey, 1988–1994,” Archives of Internal Medicine, vol. 163, no. 4, pp. 427–436, 2003.
- N. Ruderman, D. Chisholm, X. Pi-Sunyer, and S. Schneider, “The metabolically obese, normal-weight individual revisited,” Diabetes, vol. 47, no. 5, pp. 699–713, 1998.
- A. Katsuki, Y. Sumida, H. Urakawa et al., “Increased visceral fat and serum levels of triglyceride are associated with insulin resistance in Japanese metabolically obese, normal weight subjects with normal glucose tolerance,” Diabetes Care, vol. 26, no. 8, pp. 2341–2344, 2003.
- M. P. Cleary, J. R. Vasselli, and M. R. Greenwood, “Development of obesity in Zucker obese (fafa) rat in absence of hyperphagia,” The American Journal of Physiology, vol. 238, no. 3, pp. E284–E292, 1980.
- D. N. Brindley and J. C. Russell, “Animal models of insulin resistance and cardiovascular disease: some therapeutic approaches using the JCR:LA-cp rat,” Diabetes, Obesity and Metabolism, vol. 4, no. 1, pp. 1–10, 2002.
- J. Sassard, A. Larcan, J. D. Sraer et al., “Human essential hypertension and genetic hypertension in rats: The Lyon model,” Bulletin de l'Academie Nationale de Medecine, vol. 190, no. 1, pp. 111–121, 2006.
- L. Li, G. Yang, Q. Li, Y. Tang, and K. Li, “High-fat- and lipid-induced insulin resistance in rats: The comparison of glucose metabolism, plasma resistin and adiponectin levels,” Annals of Nutrition and Metabolism, vol. 50, no. 6, pp. 499–505, 2007.
- S. Tanaka, T. Hayashi, T. Toyoda et al., “High-fat diet impairs the effects of a single bout of endurance exercise on glucose transport and insulin sensitivity in rat skeletal muscle,” Metabolism, vol. 56, no. 12, pp. 1719–1728, 2007.
- C. Raffaella, B. Francesca, F. Italia, P. Marina, L. Giovanna, and I. Susanna, “Alterations in hepatic mitochondrial compartment in a model of obesity and insulin resistance,” Obesity, vol. 16, no. 5, pp. 958–964, 2008.
- R. Kleemann, M. Van Erk, L. Verschuren et al., “Time-resolved and tissue-specific systems analysis of the pathogenesis of insulin resistance,” PLoS ONE, vol. 5, no. 1, article e8817, 2010.
- M. J. Pagliassotti and P. A. Prach, “Quantity of sucrose alters the tissue pattern and time course of insulin resistance in young rats,” American Journal of Physiology, vol. 269, no. 3, part 2, pp. R641–R646, 1995.
- M. P. Thompson and D. Kim, “Links between fatty acids and expression of UCP2 and UCP3 mRNAs,” FEBS Letters, vol. 568, no. 1–3, pp. 4–9, 2004.
- J. Matsuda, K. Hosoda, H. Itoh et al., “Cloning of rat uncoupling protein-3 and uncoupling protein-2 cDNAs: their gene expression in rats fed high-fat diet,” FEBS Letters, vol. 418, no. 1-2, pp. 200–204, 1997.
- D. W. Gong, Y. He, and M. L. Reitman, “Genomic organization and regulation by dietary fat of the uncoupling protein 3 and 2 genes,” Biochemical and Biophysical Research Communications, vol. 256, no. 1, pp. 27–32, 1999.
- V. Bezaire, L. L. Spriet, S. Campbell et al., “Constitutive UCP3 overexpression at physiological levels increases mouse skeletal muscle capacity for fatty acid transport and oxidation,” FASEB Journal, vol. 19, no. 8, pp. 977–979, 2005.
- M. Nabben, J. Hoeks, E. Moonen-Kornips, et al., “Significance of uncoupling protein 3 in mitochondrial function upon mid- and long-term dietary high-fat exposure,” FEBS Letters, vol. 585, no. 24, pp. 4010–4017, 2011.
- C. S. Choi, J. J. Fillmore, J. K. Kim et al., “Overexpression of uncoupling protein 3 in skeletal muscle protects against fat-induced insulin resistance,” Journal of Clinical Investigation, vol. 117, no. 7, pp. 1995–2003, 2007.
- S. R. Costford, S. N. Chaudhry, S. A. Crawford, M. Salkhordeh, and M. E. Harper, “Long-term high-fat feeding induces greater fat storage in mice lacking UCP3,” American Journal of Physiology, vol. 295, no. 5, pp. E1018–E1024, 2008.
- L. M. Sparks, H. Xie, R. A. Koza et al., “A high-fat diet coordinately downregulates genes required for mitochondrial oxidative phosphorylation in skeletal muscle,” Diabetes, vol. 54, no. 7, pp. 1926–1933, 2005.
- M. Bajaj, R. Medina-Navarro, S. Suraamornkul, C. Meyer, R. A. DeFronzo, and L. J. Mandarino, “Paradoxical changes in muscle gene expression in insulin-resistant subjects after sustained reduction in plasma free fatty acid concentration,” Diabetes, vol. 56, no. 3, pp. 743–752, 2007.
- H. Staiger, K. Staiger, C. Haas, M. Weisser, F. MacHicao, and H. U. Häring, “Fatty acid-induced differential regulation of the genes encoding peroxisome proliferator-activated receptor-γ coactivator-1α and -1β in human skeletal muscle cells that have been differentiated in vitro,” Diabetologia, vol. 48, no. 10, pp. 2115–2118, 2005.
- E. Mormeneo, C. Jimenez-Mallebrera, X. Palomer, et al., “PGC-1alpha induces mitochondrial and myokine transcriptional programs and lipid droplet and glycogen accumulation in cultured human skeletal muscle cells,” PLoS One, vol. 7, no. 1, article e29985, 2012.
- N. Nikolic, M. Rhedin, A. C. Rustan, et al., “Overexpression of PGC-1alpha increases fatty acid oxidative capacity of human skeletal muscle cells,” Biochemistry Research International, vol. 2012, Article ID 714074, 2012.
- C. R. Benton, J. G. Nickerson, J. Lally et al., “Modest PGC-1α overexpression in muscle in vivo is sufficient to increase insulin sensitivity and palmitate oxidation in subsarcolemmal, not intermyofibrillar, mitochondria,” Journal of Biological Chemistry, vol. 283, no. 7, pp. 4228–4240, 2008.
- D. Kang, S. H. Kim, and N. Hamasaki, “Mitochondrial transcription factor A (TFAM): roles in maintenance of mtDNA and cellular functions,” Mitochondrion, vol. 7, no. 1-2, pp. 39–44, 2007.
- R. M. N. Bezerra, M. Ueno, M. S. Silva, D. Q. Tavares, C. R. O. Carvalho, and M. J. A. Saad, “A high fructose diet affects the early steps of insulin action in muscle and liver of rats,” Journal of Nutrition, vol. 130, no. 6, pp. 1531–1535, 2000.
- P. A. Hansen, D. H. Han, B. A. Marshall et al., “A high fat diet impairs stimulation of glucose transport in muscle: functional evaluation of potential mechanisms,” Journal of Biological Chemistry, vol. 273, no. 40, pp. 26157–26163, 1998.