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Oxidative Medicine and Cellular Longevity
Volume 2012 (2012), Article ID 418748, 7 pages
Ginkgo Biloba Extract EGB761 Protects against Aging-Associated Diastolic Dysfunction in Cardiomyocytes of D-Galactose-Induced Aging Rat
1Department of Gerontology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China
2Institute of Cardiovascular Disease, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China
3Department of Cardiology, Anyang Sixth People Hospital, Anyang, Henan 455000, China
4Department of Cardiology, The Shengze Hospital of Jiangsu Province, SuZhou 215002, China
Received 30 November 2011; Revised 6 March 2012; Accepted 13 March 2012
Academic Editor: Ana Fortuno
Copyright © 2012 Jing Liu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- S. Y. Li, M. Du, E. K. Dolence et al., “Aging induces cardiac diastolic dysfunction, oxidative stress, accumulation of advanced glycation endproducts and protein modification,” Aging Cell, vol. 4, no. 2, pp. 57–64, 2005.
- G. A. Silberman, T. H. M. Fan, H. Liu et al., “Uncoupled cardiac nitric oxide synthase mediates diastolic dysfunction,” Circulation, vol. 121, no. 4, pp. 519–528, 2010.
- J. Ren, Q. Li, S. Wu, S. Y. Li, and S. A. Babcock, “Cardiac overexpression of antioxidant catalase attenuates aging-induced cardiomyocyte relaxation dysfunction,” Mechanisms of Ageing and Development, vol. 128, no. 3, pp. 276–285, 2007.
- X. Song, M. Bao, D. Li, and Y. M. Li, “Advanced glycation in d-galactose induced mouse aging model,” Mechanisms of Ageing and Development, vol. 108, no. 3, pp. 239–251, 1999.
- F. Safciuc, A. Constantin, A. Manea et al., “Advanced glycation end products, oxidative stress and metalloproteinases are altered in the cerebral microvasculature during aging,” Current Neurovascular Research, vol. 4, no. 4, pp. 228–234, 2007.
- L. Van Heerebeek, N. Hamdani, M. L. Handoko et al., “Diastolic stiffness of the failing diabetic heart: importance of fibrosis, advanced glycation end products, and myocyte resting tension,” Circulation, vol. 117, no. 1, pp. 43–51, 2008.
- S. Dhar, D. Koul, and G. E. D'Alonzo, “Current concepts in diastolic heart failure,” Journal of the American Osteopathic Association, vol. 108, no. 4, pp. 203–209, 2008.
- E. Picht, J. DeSantiago, S. Huke, M. A. Kaetzel, J. R. Dedman, and D. M. Bers, “CaMKII inhibition targeted to the sarcoplasmic reticulum inhibits frequency-dependent acceleration of relaxation and Ca2+ current facilitation,” Journal of Molecular and Cellular Cardiology, vol. 42, no. 1, pp. 196–205, 2007.
- Y. C. Yeh, T. J. Liu, L. C. Wang et al., “A standardized extract of Ginkgo biloba suppresses doxorubicin-induced oxidative stress and p53-mediated mitochondrial apoptosis in rat testes,” British Journal of Pharmacology, vol. 156, no. 1, pp. 48–61, 2009.
- J. Shen, J. Wang, B. Zhao, J. Hou, T. Gao, and W. Xin, “Effects of EGb 761 on nitric oxide and oxygen free radicals, myocardial damage and arrhythmia in ischemia-reperfusion injury in vivo,” Biochimica et Biophysica Acta, vol. 1406, no. 3, pp. 228–236, 1998.
- J. G. Shen and D. Y. Zhou, “Efficiency of ginkgo biloba extract (EGb 761) in antioxidant protection against myocardial ischemia and reperfusion injury,” Biochemistry and Molecular Biology International, vol. 35, no. 1, pp. 125–134, 1995.
- C. Mozet, R. Martin, K. Welt, and G. Fitz, “Cardioprotective effect of EGb 761 on myocardial ultrastructure of young and old rat heart and antioxidant status during acute hypoxia,” Aging, vol. 21, no. 1, pp. 14–21, 2009.
- R. Schneider, K. Welt, W. Aust, H. Löster, and G. Fitzl, “Cardiac ischemia and reperfusion in spontaneously diabetic rats with and without application of EGb 761: II. Interstitium and microvasculature,” Histology and Histopathology, vol. 24, no. 5, pp. 587–598, 2009.
- T. Liebgott, M. Miollan, Y. Berchadsky, K. Drieu, M. Culcasi, and S. Pietri, “Complementary cardioprotective effects of flavonoid metabolites and terpenoid constituents of Ginkgo biloba extract (EGb 761) during ischemia and reperfusion,” Basic Research in Cardiology, vol. 95, no. 5, pp. 368–377, 2000.
- C. Schiborr, G. P. Eckert, J. Weissenberger et al., “Cardiac oxidative stress and inflammation are similar in SAMP8 and SAMR1 mice and unaltered by curcumin and Ginkgo biloba extract intake,” Current Pharmaceutical Biotechnology, vol. 11, no. 8, pp. 861–867, 2010.
- D. Jezova, R. Duncko, M. Lassanova, M. Kriska, and F. Moncek, “Reduction of rise in blood pressure and cortisol release during stress by Ginkgo biloba extract (EGb 761) in healthy volunteers,” Journal of Physiology and Pharmacology, vol. 53, no. 3, pp. 337–348, 2002.
- Y. Maejima, S. Adachi, H. Ito, K. Hirao, and M. Isobe, “Induction of premature senescence in cardiomyocytes by doxorubicin as a novel mechanism of myocardial damage,” Aging Cell, vol. 7, no. 2, pp. 125–136, 2008.
- B. Chen, Y. Zhong, W. Peng, Y. Sun, and W. J. Kong, “Age-related changes in the central auditory system: comparison of d-galactose-induced aging rats and naturally aging rats,” Brain Research C, vol. 1344, pp. 43–53, 2010.
- X. L. Xu, X. J. Chen, H. Ji et al., “Astragaloside IV improved intracellular calcium handling in hypoxia-reoxygenated cardiomyocytes via the sarcoplasmic reticulum Ca2+-ATPase,” Pharmacology, vol. 81, no. 4, pp. 325–332, 2008.
- J. V. Valencia, S. C. Weldon, D. Quinn et al., “Advanced glycation end product ligands for the receptor for advanced glycation end products: biochemical characterization and formation kinetics,” Analytical Biochemistry, vol. 324, no. 1, pp. 68–78, 2004.
- H. M. Hsieh, W. M. Wu, and M. L. Hu, “Genistein attenuates d-galactose-induced oxidative damage through decreased reactive oxygen species and NF-κB binding activity in neuronal PC12 cells,” Life Sciences, vol. 88, no. 1-2, pp. 82–88, 2011.
- X. Zhang, W. Liu, X. Niu, and L. An, “Systemic administration of catalpol prevents d-galactose induced mitochondrial dysfunction in mice,” Neuroscience Letters, vol. 473, no. 3, pp. 224–228, 2010.
- J. Pedro De Magalhães, F. Chainiaux, F. De Longueville et al., “Gene expression and regulation in H2O2-induced premature senescence of human foreskin fibroblasts expressing or not telomerase,” Experimental Gerontology, vol. 39, no. 9, pp. 1379–1389, 2004.
- G. P. Dimri, X. Lee, G. Basile et al., “A biomarker that identifies senescent human cells in culture and in aging skin in vivo,” Proceedings of the National Academy of Sciences of the United States of America, vol. 92, no. 20, pp. 9363–9367, 1995.
- D. Bernhard and G. Laufer, “The aging cardiomyocyte: a mini-review,” Gerontology, vol. 54, no. 1, pp. 24–31, 2008.
- R. Petrova, Y. Yamamoto, K. Muraki et al., “Advanced glycation endproduct-induced calcium handling impairment in mouse cardiac myocytes,” Journal of Molecular and Cellular Cardiology, vol. 34, no. 10, pp. 1425–1431, 2002.
- D. Lagadic-Gossmann, K. J. Buckler, K. Le Prigent, and D. Feuvray, “Altered Ca2+ handling in ventricular myocytes isolated from diabetic rats,” American Journal of Physiology, vol. 270, no. 5, pp. H1529–H1537, 1996.
- D. M. Bers, “Cardiac excitation-contraction coupling,” Nature, vol. 415, no. 6868, pp. 198–205, 2002.
- E. Vafiadaki, V. Papalouka, D. A. Arvanitis, E. G. Kranias, and D. Sanoudou, “The role of SERCA2a/PLN complex, Ca2+ homeostasis, and anti-apoptotic proteins in determining cell fate,” Pflugers Archiv European Journal of Physiology, vol. 457, no. 3, pp. 687–700, 2009.
- K. F. Frank, B. Bölck, E. Erdmann, and R. H. G. Schwinger, “Sarcoplasmic reticulum Ca2+-ATPase modulates cardiac contraction and relaxation,” Cardiovascular Research, vol. 57, no. 1, pp. 20–27, 2003.
- K. R. Bidasee, Y. Zhang, C. H. Shao et al., “Diabetes increases formation of advanced glycation end products on Sarco(endo)plasmic reticulum Ca2+-ATPase,” Diabetes, vol. 53, no. 2, pp. 463–473, 2004.
- R. Abdel-Kader, S. Hauptmann, U. Keil et al., “Stabilization of mitochondrial function by Ginkgo biloba extract (EGb 761),” Pharmacological Research, vol. 56, no. 6, pp. 493–502, 2007.
- J. Renugadevi and S. Milton Prabu, “Quercetin protects against oxidative stress-related renal dysfunction by cadmium in rats,” Experimental and Toxicologic Pathology, vol. 62, no. 5, pp. 471–481, 2010.