Kluyveromyces lactis: A Suitable Yeast Model to Study Cellular Defense Mechanisms against Hypoxia-Induced Oxidative Stress

Table 1

Putative main actors of aging and its signaling pathways in K. lactis and S. cerevisiae. Degree of identity (%) between homologs is indicated in Figure 2.

Protein	ORF; K. lactis	ORF; S. cerevisiae	Function
Sir2	YDL042C	KLLA0F14663g	NAD^+ -dependent histone deacetylase
Tpk1	YJL164C	KLLA0B12716g	PKA catalytic subunit
Tpk2	YPL203W	KLLA0D03190g	PKA catalytic subunit
Tpk3	YKL166C	KLLA0B07205g	PKA catalytic subunit
Bcy1	YIL033C	KLLA0E04181g	PKA regulatory subunit
Ypk3	YBR028C	KLLA0F24618g	An AGC kinase phosphorylated by cAMP-dependent protein kinase (PKA) in a TORC1-dependent manner
Asa1	YPR085C	KLLA0D09086g	Subunit of the ASTRA complex involved in the stability or biogenesis of PIKK*s such as TORC1
Tor1	YJR066W	KLLA0B13948g	PIK-related protein kinase and rapamycin target, subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport, and autophagy, involved in meiosis
Tor2	YKL203C	KLLA0B13948g	PIK-related protein kinase and rapamycin target, subunit of TORC1 and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton, involved in meiosis
Nnk1	YKL171W	KLLA0A06776g	Protein kinase, implicated in proteasome function, interacts with TORC1, Ure2, and Gdh2
Tco89	YPL180W	KLLA0E18855g	Subunit of TORC1 (Tor1 or Tor2-Kog1-Lst8-Tco89)
Kog1	YHR186C	KLLA0A09471g	Subunit of TORC1, it may act as a scaffold protein to couple TOR and its effectors
Tti1	YKL033W	KLLA0F25762g	Subunit of the ASTRA complex, involved in chromatin remodeling, telomere length regulator involved in the stability or biogenesis of PIKK*s such as TORC1
Tti2	YJR136C	KLLA0B04026g	Subunit of the ASTRA complex, involved in chromatin remodeling, telomere length regulator involved in the stability or biogenesis of PIKK*s such as TORC1
Sch9	YHR205W	KLLA0B03586g	AGC family protein kinase and functional ortholog of mammalian S6 kinase, phosphorylated by Tor1p and required for TORC1-mediated regulation of ribosome biogenesis, translation initiation, and entry into G0 phase, integrates nutrient signals and stress signals from sphingolipids to regulate life span
Maf1	YDR005C	KLLA0E17535g	Negative regulator of RNA polymerase III, binds to the N-terminal domain of the Rpc160 subunit of Pol III to prevent closed-complex formation, localization and activity are regulated by phosphorylation, mediated by TORC1, protein kinase A, and Sch9
Tel2	YGR099W	KLLA0D15158g	Subunit of the ASTRA complex, involved in the stability or biogenesis of PIKK*s such as TORC1
Sfp1	YLR403W	KLLA0B03047g	Regulates transcription of ribosomal protein, response to nutrients and stress, G2/M transitions during mitotic cell cycle, and DNA-damage response and modulates cell size, regulated by TORC1 and Mrs6 prion
Npr2	YEL062W	KLLA0D01067g	Npr2/3 complex mediates downregulation of TORC1 activity upon amino acid limitation
Npr3	YHL023C	KLLA0F18238g	Npr2/3 complex mediates downregulation of TORC1 activity upon amino acid limitation

* PIKK phosphoinositide 3-kinase related kinase.