Influence of Block of NF-Kappa B Signaling Pathway on Oxidative Stress in the Liver Homogenates

Figure 1

Liver status of the glutathione metabolism in the control group, the endothelin-1 groups, (1.25 and 12.5 μg/kg/b.w.) and BAY 11-7082 (10 mg/kg b.w.) administered 1 hour before ET-1 (12.5 μg/kg b.w.) group (𝑛=8, per group). Data is shown as mean ± S.E.M. ET-1-endothelin-1 at doses of 1.25 and 12.5 μg/kg b.w.; BAY+ET-1-BAY 11-7082 (10 mg/kg b.w.) administered 1 hour before endothelin-1 (12.5 μg/kg b.w.) group; tGSH-total glutathione; GSH-reduced glutathione; GSSG-oxidized glutathione.^∗𝑃<0.001,^∗∗𝑃<0.01, ^∗∗∗𝑃<0.02, and ^∗∗∗∗𝑃<0.05  versus saline; ^#𝑃<0.001, ^##𝑃<0.01, ^###𝑃<0.02, and ^####𝑃<0.05  versus BAY 11-7082 + ET-1; ^∧𝑃<0.001, ^∧∧𝑃<0.01  versus ET-1 (1.25 μg/kg b.w).