Table 1: Effect of administration of BAY 11-7082 on oxidative stress parameters in liver homogenates of rats with endothelin-1-induced endotoxemia. Mean ± S.E.M. ( ).

Parameter0.9% NaClET-1
(1.25 mg/kg b.w.)
ET-1
(12.5 mg/kg b.w.)
BAY 11-7082
(10 mg/kg b.w.)
+ ET 1
(12.5 mg/kg b.w.)

TBARS ( M)5.96 ± 1.07510.93 ± 1.16###22.26 ± 2.43*#0.44 ± 0.22***
( M)1.44 ± 0.15
1.79 ± 0.06****2.56 ± 0.15*##1.55 ± 0.19
GSH/GSSG ratio7.13 ± 1.093.69 ± 0.27*#3.84 ± 1.02####7.30 ± 0.46

TBARS: thiobarbituric acid-reactive substances; : hydrogen peroxide; redox status: GSH/GSSG ratio; ,** , *** , and **** versus saline; # , ## , ### , and #### versus BAY 11-7082 + ET-1; , versus ET-1 (1.25 mg/kg b.w.).