Cytokine Dysregulation in MECP2- and CDKL5-Related Rett Syndrome: Relationships with Aberrant Redox Homeostasis, Inflammation, and ω-3 PUFAs

Figure 6

Schematic cytokine changes in MECP2- and CDKL5-RTT. Data were based on comparisons between MECP2- and CDKL5-related Rett patients and healthy subjects reported in Figures 1, 2, 3, and 4. (a) and (b) The symbol , , or = indicates a significant decrease, increase, or unchanged value of the examined cytokine versus examined healthy subject values. (c) and (d) The symbol , , or = indicates a significant decrease, increase, or unchanged value of the examined cytokine versus untreated MECP2- and CDKL5-mutated Rett patients values. mainly secreted by macrophages; whose assay is not available in the ω-3 PUFAs supplemented CDKL5-RTT.

(a) MECP2-mutated Rett patients (untreated)

(b) CDKL5-mutated Rett patients (untreated)

(c) Omega-3 PUFAs supplemented MECP2-mutated Rett patients

(d) Omega-3 PUFAs supplemented CDKL5-mutated Rett patients