Possible role of aminochrome in autophagy. Aminochrome induces the dysfunction of autophagy by forming adducts with the following: (i) alpha synuclein, which inactivates chaperone-mediated autophagy; and (ii) α- and β-tubulin, inducing the aggregation of microtubules, which are essential for the fusion of autophagy vacuoles with lysosomes.
