PPAR Research

Review Article

Gene Expression Changes Induced by PPAR Gamma Agonists in Animal and Human Liver

Table 1

A literature survey of gene expression changes after treatment of in vivo and in vitro rodent liver models with PPAR agonists.
IN VIVOIN VITRO
Ref.[27][28][29][24][30][11][31][23][32][33][34][12][35][36][36][37]
model PPAR mice
PPAR 1
overexpression		AZIPWT
LKO		AZIP
LKO		ob/obZDF
rats		WT
mice		AZIPWTap2/dtasprague dawley ratsKKAob/obprimary rat hepatocytesc9 rataml-12 murine
treatmentTRO 5 d 0.1% v/vno treatmentROSI 5 w 5 mg/kg/dTRO 10 d
200 mg/
100 g chow		GW
1929 7 d
5 mg/kg/d		 ROSI
3 w 3 mg/kg/d		 TRO 5 w 16.6 mg/g chowROSI 4 d
30 mg/
kg/d		 ROSI 28 d 2.5 mg/kg/d and TRO 100 mg/kg/d dTRO 6 h
10–
200  M		TRO 24 h
5–50–
200  M		TRO,
ROSI,
PIO, CIG
6 h–10 h
5–200  M		TRO 24 h
25  M		TRO,
ROSI,
PIO 24 h
10–50–
100  M		TRO,
ROSI,
PIO, CIG
6 h–10 h
5–200  M		TRO 5 d 5  M
methodaffymetrix/q-PCRnorthern blotting northern blotting/
q-PCR		northern blottingq-PCRnorthern blottingq-PCRapplied biosystemq-PCRq-PCR/eXpressq-PCR
Por+
Oxidative stressHmox1+++
Ephx2
Nqo++
Acox1+ +
Cox2+
Serpine1
Kif5b+
Cell cycle, proliferation and deathBrca1+
Cdkn1c+
Gadd45a
Kif24+
Gadd153++
Atf3+
Bcl2l11+
Blnk+
p21++
Gadd45g+++
Cflar+
Egr1+
Emp2+
Fem1b+
Fhl2+
Fos+
Herpud1+
Hmga1+
Igfbp1+
Igfbp6+
Il7+
Lats1+
Mt1a+
Nr1d1+
Phlda1+
Sfn+
Skil+
Stk17b+
Bid3+
Ckn1b+
Cldnk4+
Myd116+
Trp53inp1+
S100a10+
Kif5b+
Il7
Actn1+
Cdh1
Gsn
Ucp2++
Fsp27++
Lipid metabolismAcaca+ +
Lipe+
Srebp100+
Fabp4+++++
Adfp+ +
Cd36+++ ++
Cpt1a+ 000
Cpt1b+ 000
Pex11a+
Acsl5+
Apoc30
Dci
Elovl4+
Fabp5+
Fasn+ ++ +
Ldlr++
Lipc+++
Acdl
Thiolase+
Kiaa1881++
Lamb3+
Me1++
Mttp
Peci
Pnpla2+
Scd1+ ++
Cyp1a10
Xenobiotic metabolismCyp1a2 0
Cyp2b1++
Cyp2b2+
Cyp2b6+
Cyp3a+
Cyp3a1++
Cyp3a3+
Cyp4b1+
Cyp4a10+++
Cyp4a14++
Cyp51a1+
Gsta2
G6pc
Carbohydrate metabolismPdk4+
Pepck
Gk+
Irs2
Pc++
Aqp7+
Abcb1+
TransportersAbcc3:+
Slco1b1+
Slco1b3
Mdr2+
Slco4a1+
Slc25a1+
Nr1i3+
Nuclear receptorsHnf4a
Ppara+ +00
Pparg++ ++ +++
Cebpa
Pparg1++
Pparg2+
Ces3
Hspa1+
Il6r+
Vnn1+
Scd2+
Actg1+
Adipoq++
Cav1++
Cav2+
Cfd++
Lrp1+++
MiscellanousMapk+
Paqr7+
Tmem159+
Tpm2+
Aco+
Aox+++++
growth response protein+
Fdft1+
Hex+
Hmgcs2
Igh-6+
Il8bp
Ldh-a+
: up-regulated
: down-regulated
0: not modulated
The case is empty when the gene has not been studied.