Coordinate Transcriptomic and Metabolomic Effects of the Insulin Sensitizer Rosiglitazone on Fundamental Metabolic Pathways in Liver, Soleus Muscle, and Adipose Tissue in Diabetic db/db Mice
Figure 6
Expression profiles of key genes involved in Soleus muscle glucose and lipid metabolism. Differentially expressed genes in db/+ (the white square) and 10 (the off-white square), 30 (the grey square), and 100 (the black square) mg/kg RSG-treated db/db mice were measured versus untreated db/db and plotted as the mean (% increase/decrease of db/db control) SEM (). NS; otherwise . (a) Genes related to glucose metabolism*: Eno3, enolase 3, beta muscle; Hk1, hexokinase 1; Pkm2, pyruvate kinase, muscle; Pgm2, phosphoglucomutase 2; Pygm, muscle glycogen phosphorylase. (b) Genes related to lipid metabolism: Dgat2, diacylglycerol O-acyltransferase 2; Lipe, lipase hormone sensitive; *gene abbreviations given in Figures 1, and 4 were not mentioned.
