219706.fig.001a
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219706.fig.001b
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Figure 1: White matter hemorrhages associated with DKA. (a) This low-power view of a gyrus (stained with hematoxylin, eosin, and Luxol fast blue) illustrates multiple small and microscopic hemorrhages (arrowheads) associated with “confluent” pallor (asterisks) of the myelin, a thin layer of preserved subcortical myelin (arrows), and normal cortex. (b) A vessel, labeled 𝑉 , is identified for reference. Stained with Luxol fast blue, hematoxylin, and eosin (which stains myelin blue). Central hemorrhage was formed by perivascular necrosis (arrow), a concentric ring of red blood cells, and diffusely rarefied white matter that is speckled with eosinophilic astrocytes (arrowheads). Figure 1 reproduced with permission from Pediatrics, volume 126, page 1543, copyright 2007 by the AAP.,