Plasmalogens Inhibit APP Processing by Directly Affecting γ-Secretase Activity in Alzheimer’s Disease
Figure 5
Effect of PC-PL 18 : 1, PC-PL 20 : 4, PC-PL 22 : 6, and PE-PL 22 : 6 on α-secretase activity. PC-PL 18 : 1, PC-PL 20 : 4, PC-PL 22 : 6 and PE-PL 22 : 6 and the corresponding phospholipids (100 μM) were incubated on purified membranes of (a) human SH-SY5Y cells and (b) mouse brains, and α-secretase activity was determined as described in materials and methods. (a, b) Representative kinetics were shown for PC-PL 18 : 1 and PC 18 : 1. All quantified data represent an average of at least three independent experiments. Illustration and statistical significance as described for Figure 2.
