General and Electrophysiological Toxic Effects of Manganese in Rats following Subacute Administration in Dissolved and Nanoparticle Form

Table 2

Body weight gain of the rats during the treatment period.

Group	Body weight gain (g)	Summed Mn dose (mg Mn°/animal)
C3	161.7 ± 14.4	—
VC3	149.9 ± 11.2	—
MnL3	149.2 ± 13.9 (99.6%)	17.94 ± 0.52
MnH3	143.7 ± 23.6 (95.9%)	71.58 ± 2.93
C33	234.2 ± 19.7	—
VC33	218.4 ± 20.9	—
MnL33	210.9 ± 17.2* (96.5%)	28.46 ± 0.55
MnH33	195.2 ± 27.6^**# (89.4%)	83.42 ± 2.95
C6	234.2 ± 25.0	—
VC6	235.2 ± 15.3	—
MnL6	226.1 ± 17.3 (96.2%)	44.55 ± 1.00
MnH6	211.0 ± 19.3^# (89.7%)	178.43 ± 8.53

For group codes, see Table 1. The data represent group averages (mean ± SD, 𝑛=8) of the difference between body weight on day 0 (before the first Mn administration) and the day of sacrifice.
* , **: 𝑃<0.05, 0.01 versus C; ^#: 𝑃<0.05 versus VC.
Percent values in parentheses represent the weight gain in the Mn-treated groups compared to that in the corresponding VC group.