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Journal of Biomedicine and Biotechnology
Volume 2011 (2011), Article ID 373781, 8 pages
The Effects of Erythropoietin Dose Titration during High-Fat Diet-Induced Obesity
Molecular Medicine Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Received 16 September 2010; Revised 24 January 2011; Accepted 3 February 2011
Academic Editor: Oreste Gualillo
Copyright © 2011 Amanda Foskett et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- D. Yach, D. Stuckler, and K. D. Brownell, “Epidemiologic and economic consequences of the global epidemics of obesity and diabetes,” Nature Medicine, vol. 12, no. 1, pp. 62–66, 2006.
- G. S. Hotamisligil, “Inflammation and metabolic disorders,” Nature, vol. 444, no. 7121, pp. 860–867, 2006.
- S. E. Shoelson, J. Lee, and A. B. Goldfine, “Inflammation and insulin resistance,” Journal of Clinical Investigation, vol. 116, no. 7, pp. 1793–1801, 2006.
- S. Schenk, M. Saberi, and J. M. Olefsky, “Insulin sensitivity: modulation by nutrients and inflammation,” Journal of Clinical Investigation, vol. 118, no. 9, pp. 2992–3002, 2008.
- V. Z. Rocha and P. Libby, “Obesity, inflammation, and atherosclerosis,” Nature reviews. Cardiology, vol. 6, no. 6, pp. 399–409, 2009.
- L. A. Szczech, H. X. Barnhart, S. Sapp et al., “A secondary analysis of the CHOIR trial shows that comorbid conditions differentially affect outcomes during anemia treatment,” Kidney International, vol. 77, no. 3, pp. 239–246, 2010.
- A. K. Singh, L. Szczech, K. L. Tang et al., “Correction of anemia with epoetin alfa in chronic kidney disease,” The New England Journal of Medicine, vol. 355, no. 20, pp. 2085–2098, 2006.
- G. L. Semenza, S. T. Koury, M. K. Nejfelt, J. D. Gearhart, and S. E. Antonarakis, “Cell-type-specific and hypoxia-inducible expression of the human erythropoietin gene in transgenic mice,” Proceedings of the National Academy of Sciences of the United States of America, vol. 88, no. 19, pp. 8725–8729, 1991.
- G. L. Semenza, “Involvement of oxygen-sensing pathways in physiologic and pathologic erythropoiesis,” Blood, vol. 114, no. 10, pp. 2015–2019, 2009.
- E. B. Rankin, M. P. Biju, Q. Liu et al., “Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivo,” Journal of Clinical Investigation, vol. 117, no. 4, pp. 1068–1077, 2007.
- S. Pelletier, S. Gingras, M. Funakoshi-Tago, S. Howell, and J. N. Ihle, “Two domains of the erythropoietin receptor are sufficient for Jak2 binding/activation and function,” Molecular and Cellular Biology, vol. 26, no. 22, pp. 8527–8538, 2006.
- N. Kertesz, J. Wu, T. H.-P. Chen, H. M. Sucov, and H. Wu, “The role of erythropoietin in regulating angiogenesis,” Developmental Biology, vol. 276, no. 1, pp. 101–110, 2004.
- H. Wu, S. H. Lee, J. Gao, X. Liu, and M. L. Iruela-Arispe, “Inactivation of erythropoietin leads to defects in cardiac morphogenesis,” Development, vol. 126, no. 16, pp. 3597–3605, 1999.
- X. Yu, J. J. Shacka, J. B. Eells et al., “Erythropoietin receptor signalling is required for normal brain development,” Development, vol. 129, no. 2, pp. 505–516, 2002.
- C. J. Parsa, A. Matsumoto, J. Kim et al., “A novel protective effect of erythropoietin in the infarcted heart,” Journal of Clinical Investigation, vol. 112, no. 7, pp. 999–1007, 2003.
- M. Sakanaka, T. C. Wen, S. Matsuda et al., “In vivo evidence that erythropoietin protects neurons from ischemic damage,” Proceedings of the National Academy of Sciences of the United States of America, vol. 95, no. 8, pp. 4635–4640, 1998.
- M. Bernaudin, H. H. Marti, S. Roussel et al., “A potential role for erythropoietin in focal permanent cerebral ischemia in mice,” Journal of Cerebral Blood Flow and Metabolism, vol. 19, no. 6, pp. 643–651, 1999.
- P. Hojman, C. Brolin, H. Gissel et al., “Erythropoietin over-expression protects against diet-induced obesity in mice through increased fat oxidation in muscles,” PLoS One, vol. 4, no. 6, Article ID e5894, 2009.
- O. Katz, M. Stuible, N. Golishevski et al., “Erythropoietin treatment leads to reduced blood glucose levels and body mass: insights from murine models,” Journal of Endocrinology, vol. 205, no. 1, pp. 87–95, 2010.
- J. R. Wright, Y. C. Ung, J. A. Julian et al., “Randomized, double-blind, placebo-controlled trial of erythropoietin in non-small-cell lung cancer with disease-related anemia,” Journal of Clinical Oncology, vol. 25, no. 9, pp. 1027–1032, 2007.
- J. D. Rizzo, M. Brouwers, P. Hurley et al., “American Society of Hematology/American Society of Clinical Oncology clinical practice guideline update on the use of epoetin and darbepoetin in adult patients with cancer,” Blood, vol. 116, no. 20, pp. 4045–4059, 2010.
- M. Ogilvie, X. Yu, V. Nicolas-Metral et al., “Erythropoietin stimulates proliferation and interferes with differentiation of myoblasts,” Journal of Biological Chemistry, vol. 275, no. 50, pp. 39754–39761, 2000.
- T. Petruschke and H. Hauner, “Tumor necrosis factor-α prevents the differentiation of human adipocyte precursor cells and causes delipidation of newly developed fat cells,” Journal of Clinical Endocrinology and Metabolism, vol. 76, no. 3, pp. 742–747, 1993.
- X. Chen, K. Xun, L. Chen, and Y. Wang, “TNF-α, a potent lipid metabolism regulator,” Cell Biochemistry and Function, vol. 27, no. 7, pp. 407–416, 2009.
- M. G. Netea, L. A. B. Joosten, E. Lewis et al., “Deficiency of interleukin-18 in mice leads to hyperphagia, obesity and insulin resistance,” Nature Medicine, vol. 12, no. 6, pp. 650–656, 2006.
- E. P. Zorrilla, M. Sanchez-Alavez, S. Sugama et al., “Interleukin-18 controls energy homeostasis by suppressing appetite and feed efficiency,” Proceedings of the National Academy of Sciences of the United States of America, vol. 104, no. 26, pp. 11097–11102, 2007.
- N. Seubert, Y. Royer, J. Staerk et al., “Active and inactive orientations of the transmembrane and cytosolic domains of the erythropoietin receptor dimer,” Molecular Cell, vol. 12, no. 5, pp. 1239–1250, 2003.