Targeting PML-RARα and Oncogenic Signaling Pathways by Chinese Herbal Mixture Tien-Hsien Liquid in Acute Promyelocytic Leukemia NB4 Cells

Figure 9

Schematic illustration of the inhibitory effects of THL and its active fraction EAS5 on the oncogenic signaling pathways in NB4 cells. The arrow indicates promotion, and the T-shaped bar indicates repression. The dramatic inhibition on ERK pathway is indicated by a thicker T-shaped bar. The data of THL are presented in Figure 8, and the data of EAS5 are presented in Figure 13.