Age-Dependent Switch of the Role of Serotonergic 5-HT_1A Receptors in Gating Long-Term Potentiation in Rat Visual Cortex In Vivo

Figure 5

The effect of application (in V1 by means of reverse microdialysis) of either aCSF (; same group as in Figure 3) or WAY 100635 (1 mM, ) on LTP following TBS (at arrow) of the LGN in urethane-anesthetized rats. Application of WAY 100635 resulted in a significant increase in LTP relative to control animals. Inserts depict typical fPSPs before (red) and after (blue) LTP induction in the presence of WAY 100635 (top) and aCSF (bottom; calibration bars indicate 0.5 mV vertical and 10 ms horizontal; each fPSP trace is an average of 30 min of continuous recording). indicates a significant (, -test) difference between the two groups.