Survival and Histopathological Study of Animals Bearing Ehrlich
Tumor Treated With a Rhodium(II) Amidate
Breno Pannia Espósito,1Szulim Ber Zyngier,2Renato Najjar,1Roberto Pinto Paes,3Suely M. Ykko Ueda,3and José Carlos A. Barros3
Received28 Sept 1998
Accepted09 Oct 1998
Abstract
The survival of 90% of a tumor-bearing population treated with the complex Rh2(CF3CONH)4
was
examined and the pharmacological parameter Surv90
determined. Histopathological alterations raised for this
drug in several tissues were studied in Balb-c mice. A Surv90
dose of 3.8x 10−5
mol/kg was found.