Hormone Anchored Metal Complexes. 1. Synthesis, Structure,
Spectroscopy and <em>In Vitro</em> Antitumor Activity of Testosterone
Acetate Thiosemicarbazone and its Metal Complexes

Murugkar, Anupa; Unnikrishnan, Bindu; Padhye, Subhash; Bhonde, Ramesh; Teat, Simon; Triantafillou, Evangelia; Sinn, Ekkehard

doi:https://doi.org/10.1155/MBD.1999.177

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Volume 6 | Article ID 863236 | https://doi.org/10.1155/MBD.1999.177

Hormone Anchored Metal Complexes. 1. Synthesis, Structure, Spectroscopy and In Vitro Antitumor Activity of Testosterone Acetate Thiosemicarbazone and its Metal Complexes

Anupa Murugkar,¹Bindu Unnikrishnan,¹Subhash Padhye,¹Ramesh Bhonde,²Simon Teat,³Evangelia Triantafillou,⁴and Ekkehard Sinn⁴

Received31 Mar 1999

Accepted30 Apr 1999

Abstract

Testosterone acetate thiosemicarbazone (TATSC, 17-β -hydroxyandrost-4-one acetate thiosemicarbazone) was synthesized and characterized by single crystal X-ray structure determination. The copper and platinum complexes of this steroid derivative were synthesized and characterized by spectroscopy and electrochemiatry. The in vitro activity of these compounds against human breast cancer cell line MCF-7 was tested. The highest activity was found for the [Pt(TATSC)Cl2] followed by [Cu(TATSC)Cl2] and the ligand in compariosn with cisplatin.

Copyright

Copyright © 1999 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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