Antidepressant Interactions with the NMDA NR1-1b Subunit
Figure 4
ANS binding. To 5.29M NR1-1b S1S2 in buffer 3 was added ANS in
a 1 : 1 molar ratio along with a TCA, SSRI, or SNRI in the following final
concentrations: (a) TCAs-desipramine (- - -): 137M, trimipramine (): 137M, maprotiline (): 3.18 mM; (b)
TCAs-nortriptyline (): 2.08 mM;
(c) SNRI-venlafaxine (- - -): 2.76 mM; (d) SSRI-fluvoxamine (- - -): 2.81 mM, paroxetine (): 3.75 mM, sertraline (): 1.88 mM; (e) SSRI-fluoxetine (- - -): 862M. In all figures the solid line is the
extrinsic fluorescence of ANS:NR1-1b S1S2. In all figures, intensities were
corrected by subtracting the drug and ANS blank.