Metallocene Antimalarials: The Continuing Quest

<table class="table-group" id="tab3"><tr><td><table class="table"><tr><td class="thead-hr" colspan="3"><hr/></td></tr><tr class="thead"><td align="left" rowspan="2">Compound</td><td align="center">D10</td><td align="center">K1</td></tr><tr class="thead"><td align="center">IC50/nM</td><td align="center">IC50/nM</td></tr><tr><td class="thead-hr" colspan="3"><hr/></td></tr><tr><td align="left">CQ·2H3PO4</td><td align="center">23</td><td align="center">352</td></tr><tr><td align="left">2Fe</td><td align="center">18</td><td align="center">14</td></tr><tr><td align="left">2Ru</td><td align="center">19</td><td align="center">13</td></tr><tr><td align="left"> 2′Fe</td><td align="center">19</td><td align="center">49</td></tr><tr><td align="left">2′Ru</td><td align="center">25</td><td align="center">29</td></tr><tr><td align="left">3aFe</td><td align="center">33</td><td align="center">37</td></tr><tr><td align="left">3aRu</td><td align="center">20</td><td align="center">20</td></tr><tr><td align="left">3a′Fe</td><td align="center">16</td><td align="center">65</td></tr><tr><td align="left">3a′Ru</td><td align="center">34</td><td align="center">127</td></tr><tr class="table-tr"><td colspan="3"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

Results of in vitro antimalarial tests conducted on the chloroquine-sensitive (D10) and
chloroquine-resistant (K1) strains of P. falciparum.

Metal-Based Drugs

Metallocene Antimalarials: The Continuing Quest

Table 3