Metal-Based Drugs / 2008 / Article / Tab 4 / Review Article
Metallocene Antimalarials: The Continuing Quest Table 4 In vitro activity of coordination complexes and the free 4-aminoquinoline ligands in chloroquine-sensitive (D10) and chloroquine-resistant (K1) strains of P. falciparum.
Compound D10 (CQ sensitive) K1 (CQ resistant) IC50 (nM) IC50 (nM) L1 37.10 570.0 [Au(L1 )(PPh3 )]NO3 21.09 61.53 [Au(C6 F5 )(L1 )] 18.07 61.09 [Rh(Cl)(COD)(L1 )] 21.50 81.31 L2 16.30 4.96 [Au(L2 )(PPh3 )]NO3 10.50 5.68 [Au(C6 F5 )(L2 )] 10.08 3.96 [Rh(Cl)(COD)(L2 )] 15.80 10.55 L3 11.30 12.56 [Au(L3 )(PPh3 )]NO3 33.27 33.89 [Au(C6 F5 )(L3 )] 13.70 14.65 [Rh(Cl)(COD)(L3 )] 202.00 597.59 L4 16.54 15.54 [Au(L4 )(PPh3 )]NO3 30.32 31.09 [Au(C6 F5 )(L4 )] 23.36 12.92 [Rh(Cl)(COD)(L4 )] 56.10 47.70