Synthesis and Cytotoxicity Studies of Titanocene C Analogues

<table>Numbering scheme of <b>5c</b> and Titanocene <svg height="12.1875" id="M64" style="vertical-align:-0.25935pt" version="1.1" viewbox="0 0 12.4 12.1875" width="12.4" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.017,-0,0,-.017,.062,11.813)"><path d="M657 152l30 -25q-69 -85 -133 -115q-63 -31 -155 -31q-159 0 -255 96q-95 98 -95 246q0 161 97 264q98 104 250 104q69 0 156 -35q26 -10 37.5 -13.5t22 2t14.5 12.5t16 31h27v-235h-25q-24 64 -67 115q-75 90 -167 90q-80 0 -133 -84q-51 -82 -51 -229q0 -155 54 -240
q22 -34 62.5 -55t84.5 -21q65 0 126 34q41 23 104 89z" id="x1D402"></path></g>
</svg> for the
structural DFT discussion of <b>5c</b>.</table>

Metal-Based Drugs

sch2

Scheme 2

Scheme 2: Synthesis and Cytotoxicity Studies of Titanocene C Analogues 