Hypertension promoted AD-type neuropathology in Tg2576 brains. (a), (b) Assessment of spatial memory in hypertensive Tg 2576 mice versus control normotensive mice by MWM test showed no effect of hypertension in the inability to learn of Tg 2576. Latency score represents time taken to escape to the platform from the water. (a) Visible platform acquisition. (b) Hidden platform acquisition. (c) A 2-month period of hypertension significantly increased the accumulation of A1-40 and A1-42 peptides by 57 and 51%, respectively, in brain tissue of Tg2576 mice. (d) This increase of Ab peptides in the brain was accompanied by a significant 30% reduction of both A1-42 and A1-40 peptides in the serum of Tg2576 mice. Values represent mean ± SEM values, mice per group. Differences between means were analyzed using two-tailed Student’s test versus control mice, .