Research Article
Sex Disparity in Food Allergy: Evidence from the PubMed Database
Table 1
Sex disparity in food allergy reporting: implications for clinical and translational research.
| | Findings from our research | Questions to consider |
| | In children: | - Does maternal imprinting and/or epigenetic modification differentially target sex in-utero with regard to food allergy? | | Greater than 64% of the reported food allergies to 11 major foods involve boys | - Is there a difference in exposure to allergenic foods among males and females? | | - Is there a sex disparity in neonatal/postnatal immune response to allergenic foods? | | - Is there a sex disparity in the quality (intensity and/or frequency) of clinical response to allergenic foods upon re-exposure among children? |
| | In adults: | - Is there a sex disparity in the outgrowing of food allergy during late childhood or adulthood? | | Greater than 65% of the reported food allergies to 11 major foods involve women | - Is there a difference in exposure to allergenic foods among males and females? | | - What is the impact of the menstrual cycle, pregnancy, and sex hormones on allergic response to foods? | | - Is there a sex disparity in the quality (intensity and/or frequency) of clinical response to allergenic foods upon re-exposure? | | - Do psychosocial factors contribute to sex disparity in food allergy reporting? | | - Does the sex disparity reflect a difference in food allergy or sensitization to aeroallergens resulting in oral allergy syndrome? |
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