Metal-Based Drugs

Research Article

Inhibitory Effects of the Ruthenium Complex KP1019 in Models of Mammary Cancer Cell Migration and Invasion

Table 1

Effect of KP418 and KP1019 on cell viability.


	MDA-MB-231	MCF-7	HBL-100

Controls	2.284 0.066	2.631 0.055	2.308 0.424
KP418 ( M )	1.832 = 0.04	2.763 0.040	2.269 0.159
	(79.9%)	(105%)	(97.0%)

	MDA-MB-231	MCF-7	HBL-100
Controls	1.482 0.016	1.178 0.073	0.999 0.055
KP1019 ( M)	1.435 0.040	1.184 0.051	1.076 0.055
	(96.8%)	(101%)	(107%)
KP1019 ( M)	1.361 0.05	1.04 0.03	0.901 0.081
	(91.8%)	(88.3%)	(90.2%)
KP1019 ( M)	0.847 0.02	0.862 0.09	0.328 0.05
	(57.2%)	(73.2%)	(32.9%)

MDA-MB-231, MCF-7, and HBL-100 cells were treated for 1 hour with KP418 M and KP1019 M, then the cells were removed from the flasks, collected, resuspended in culture medium and seeded on 96 well plates. After 24 hours cell viability was determined by the MTT assay. Data are the mean optical density S.D. of two experiments each performed in quadruplicate. Data in parentheses represent the percentage of each treated group versus the relevant controls (T/C%),: , : versus controls, ANOVA, and Tukey-Kramer post test.