Research Article
Inhibitory Effects of the Ruthenium Complex KP1019 in Models of Mammary Cancer Cell Migration and Invasion
Table 2
Effect of KP1019 on lung metastases formation in mice with MCa mammary carcinoma.
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Groups of 9 (experiment A) or 11 (experiment B) CBA mice, inoculated I.M. with MCa tumour cells on day 0 were treated I.P. with KP1019 at 40 mg/kg/day from day 6 to day 11 (A) and 80 mg/kg/day on days 7, 9, and 11 (B) after tumour implant. Data in parentheses are expressed as the percentage of the treated versus controls (T/C%), Lung metastases were determined on day 20 after tumour implant, : versus controls, ANOVA, and Tukey-Kramer post test, #: excluded the animals free of macroscopically detectable metastasis (2/11). |