Review Article
Hypersensitivity Reactions Associated with Platinum Antineoplastic Agents: A Systematic Review
Table 1
Incidence and severity of hypersensitivity to platinum agents.
| Drug | Overall incidence % | Characteristics/Severity |
| Cisplatin | 5–20 | Occurs within minutes of infusion start | Mostly between 4th–8th course | Increases with concomitant radiation |
| Carboplatin | 1–44 | Occurs within minutes or days from infusion | less than 1% during cycles 1–5 | 6.5% in cycle 6 | 27% in cycle 7 or more | 44% in 3rd-line retreatment | Half of all reactions observed are moderate to severe |
| Oxaliplatin | 10–18.9 | Occurs within minutes/hours from infusion | Mostly after 6th course | Grade 3-4 in only 1.6% | Severe anaphylaxis mostly in case reports |
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