Metal-Based Drugs

Review Article

Hypersensitivity Reactions Associated with Platinum Antineoplastic Agents: A Systematic Review

Table 3

Emergency procedures in case of hypersensitivity reactions.
Emergency procedures in case of hypersensitivity reaction to a platinum agent
(1) Interruption of infusion
(2) Administer: i.v. antihistamines (type 1 and 2 histamine receptor antagonists), normal saline infusion, and low-dose corticosteroids
 (antihistamines are the first to be administered)
(3) In case of a more severe reaction (dyspnoea, laryngospasm, bronchospasm):
 (i) oxygen, bronchodilators
 (ii) high dose steroids (doses range between 100 and 1000 mg of hydrocortisone)
(4) Administer epinephrine in case of hypotension or airway obstruction symptoms
(5) Monitoring until symptoms resolve or for several hours later in case of severe hypersensitivity