p73-Binding Partners and Their Functional Significance
Figure 1
Dominant-negative effect of ΔNp73 on wild-type p73. In response to DNA damage, wild-type p73 transactivates its dominant-negative inhibitor ΔNp73. The intracellular balance between the expression levels of wild-type p73 and ΔNp73 is a critical determinant of cell fate.
