Thrombosis / 2010 / Article / Tab 1 / Review Article
Porcine and Canine von Willebrand Factor and von Willebrand Disease: Hemostasis, Thrombosis, and Atherosclerosis Studies Table 1 Differential correction of phenotype of VWD swine by transplantation of liver, kidney, bone marrow, and lung.
VWF Transplant procedure Cell(s) synthesizing VWF Plasma Platelet F.VIII Bleeding time [25 ] Thrombosis References None None None None Low Prolonged Not done [14 , 25 ] Normal liver to VWD Hepatic endothelium Near normal to normal Not done Near normal to normal Near normal to normal Not done [26 ] Normal kidney to VWD Presumed endothelium None Not done Low Prolonged Not done [26 ] Normal bone marrow to VWD Megakaryocyte Little to none Present Low Prolonged No [9 , 27 , 28 ] VWD bone marrow to normal Endothelium Normal Absent Normal Near normal to normal Yes [9 , 28 ] Normal Lung to VWD Pulmonary endothelium ~5% Absent Prolonged Not done [29 ]
Adapted with permission from Brinkhous KM, Reddick RL, Read MS, Nichols TC, Bellinger DA, Griggs TR. von Willebrand factor, and animal models: contributions to gene therapy, thrombotic thrombocytopenic purpura, and coronary artery thrombosis. Mayo Clin Proc. 1991; 66 : 733–742 [30 ].
